Humanitarian emergencies in countries with a high HIV disease burden can cause considerable PMTCT antiretroviral treatment (ART) interruption. The risk of drug resistance emerging is increased, efficacy of treatment compromised and the effective scale-up of lifelong ART for pregnant and breastfeeding women living with HIV is impeded. Therefore, strategies to ensure the uninterrupted supply of antiretrovirals for PMTCT during crises are needed. This paper highlights lessons learned from PMTCT implementation in emergencies based on reported literature, key informant interviews, and recommendations made. The review focuses on delivering ART for PMTCT.